Every once in a while, it becomes necessary to delete a file in your code. Here is how you do that:

C#
FileInfo TheFile = new FileInfo(MapPath(".") + "\\" + txtFile.Text);
if (TheFile.Exists) {
File.Delete(MapPath(".") + "\\" + txtFile.Text);

VB
Dim TheFile As FileInfo = New FileInfo((MapPath(".") + ("\\" + txtFile.Text)))
If TheFile.Exists Then
    File.Delete((MapPath(".") + ("\\" + txtFile.Text)))
End If